ParkinsonFranceV1, Main, Exploration, bibRecord, 000060

Ambroxol effects in glucocerebrosidase and α-synuclein transgenic mice.

Identifieur interne : 000060 ( Main/Exploration ); précédent : 000059; suivant : 000061

Ambroxol effects in glucocerebrosidase and α-synuclein transgenic mice.

Auteurs : Anna Migdalska-Richards [Royaume-Uni] ; Liam Daly [Royaume-Uni] ; Erwan Bezard [France] ; Anthony H V. Schapira [Royaume-Uni]

Source :

Annals of Neurology [ 0364-5134 ] ; 2016-11.

RBID : Hal:hal-01456949

Abstract

Gaucher disease is caused by mutations in the glucocerebrosidase 1 gene that result in deficiency of the lysosomal enzyme glucocerebrosidase. Both homozygous and heterozygous glucocerebrosidase 1 mutations confer an increased risk for developing Parkinson disease. Current estimates indicate that 10 to 25% of Parkinson patients carry glucocerebrosidase 1 mutations. Ambroxol is a small molecule chaperone that has been shown to increase glucocerebrosidase activity in vitro. This study investigated the effect of ambroxol treatment on glucocerebrosidase activity and on α-synuclein and phosphorylated α-synuclein protein levels in mice.

Url:

https://hal.archives-ouvertes.fr/hal-01456949

DOI: 10.1002/ana.24790.

Affiliations:

France, Royaume-Uni

Links toward previous steps (curation, corpus...)

to stream Hal, to step Corpus: 000070
to stream Hal, to step Curation: 000070
to stream Hal, to step Checkpoint: 000021
to stream Main, to step Merge: 000060
to stream Main, to step Curation: 000060

Le document en format XML

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<front><div type="abstract" xml:lang="0">Gaucher disease is caused by mutations in the glucocerebrosidase 1 gene that result in deficiency of the lysosomal enzyme glucocerebrosidase. Both homozygous and heterozygous glucocerebrosidase 1 mutations confer an increased risk for developing Parkinson disease. Current estimates indicate that 10 to 25% of Parkinson patients carry glucocerebrosidase 1 mutations. Ambroxol is a small molecule chaperone that has been shown to increase glucocerebrosidase activity in vitro. This study investigated the effect of ambroxol treatment on glucocerebrosidase activity and on α-synuclein and phosphorylated α-synuclein protein levels in mice.</div>
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	La maladie de Parkinson en France (serveur d'exploration)
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La maladie de Parkinson en France (serveur d'exploration)

Ambroxol effects in glucocerebrosidase and α-synuclein transgenic mice.

Ambroxol effects in glucocerebrosidase and α-synuclein transgenic mice.

Source :

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

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